{"id":6574,"date":"2020-07-20T12:50:41","date_gmt":"2020-07-20T07:50:41","guid":{"rendered":"https:\/\/drmohans.com\/?p=6574"},"modified":"2024-11-27T09:59:39","modified_gmt":"2024-11-27T09:59:39","slug":"does-obesity-always-mean-t2dm","status":"publish","type":"post","link":"https:\/\/drmohans.com\/backend\/does-obesity-always-mean-t2dm\/","title":{"rendered":"Does Obesity Always Mean T2DM (Type 2 Diabetes mellitus)?"},"content":{"rendered":"\r\n

Type 2 diabetes mellitus<\/strong>, also known as\u00a0T2DM<\/strong>\u00a0is a chronic metabolic disorder caused by high levels of blood sugar, due to the body\u2019s inability to produce insulin (insulin deficiency) and that of the peripheral organs to respond appropriately to insulin (peripheral insulin resistance). Apart from being called a disease of \u201cimpaired glucose metabolism\u201d, it is also a disease of \u201cimpaired fat metabolism\u201d. Research in recent times has shown that obesity could cause\u00a0Type 2\u00a0Diabetes\u00a0<\/strong>in this way. Let\u2019s see how this happens.<\/p>\r\n

How does fat accumulate in the body?<\/strong><\/p>\r\n\r\n\r\n\r\n\r\n\r\n

The abnormal gain of fat mass is generally due to overconsumption of carbohydrates, sugar, fat, oils, etc. and underutilization of the excess energy obtained in this way (on account of low levels of physical activity). In instances of overconsumption of carbs, a hormone in our body called leptin is triggered to alert the brain to reduce the appetite, to tell the body to exercise and be more physically active, so that more calories are burnt. With an increase in the fat mass in the body, leptin gets stimulated which in turn alerts the brain. This is a natural way to maintain a balance in the body. Prolonged higher levels of leptin in the blood cause leptin resistance, meaning the brain is unable to recognize these high levels of leptin and thus loses the ability to command the body to burn more fat. This results in the accumulation of fats in tissues such as the liver, pancreas, and heart, eventually leading to cardiovascular disease and other complications.<\/p>\r\n\r\n\r\n\r\n

Not all obese people necessarily develop\u00a0Type 2 Diabetes<\/strong>. This is mainly related to the way in which fat cells get accumulated in the body. There are 2 ways in which excess fat gets stored \u2013 one, beneath the skin (subcutaneous) and the other is in the abdominal cavity (viscera\/Waist) of obese patients. Compared to the abdomen, fat deposited under the skin is relatively harmless as it does not produce harmful hormones (adipocytokines). The skin has more space to store fat since it is the largest organ in the body. However, the fat that gets accumulated within the abdomen and around internal organs is more toxic. Fat that gets stored here tends to be metabolically more active. Hence these fat cells tend to produce more adipocytokines, the inflammatory hormones which enhances insulin resistance All in all, increased amount of visceral fat is directly and independently linked to several complications such as insulin resistance,\u00a0 \u00a0altered glucose tolerance, type 2 diabetes, high cholesterol levels, heart diseases, etc.<\/p>\r\n

The best way to detect excess visceral fat is by measuring the waist circumference or the waist to hip ratio. High waist circumference and waist-to-hip ratio increase the risk of diabetes.<\/p>\r\n

Research has shown that overweight or obese people with reasonable waist circumference and waist-to-hip ratio have better prospects compared to normal-weight people with unusual belly fat who showed a higher risk of Type 2 Diabetes<\/strong>. Further, the greater the muscular mass in the body, the higher the sugar metabolizing capacity and thus, lower the risk of\u00a0T2DM<\/strong>.<\/p>\r\n

All obese need not have diabetes<\/strong><\/p>\r\n\r\n\r\n\r\n\r\n\r\n\r\n\r\n

The above data shows that the risk of developing\u00a0Type 2 Diabetes<\/strong>\u00a0does not fully depend on whether an individual is thin or fat. What matters more is where the excess fat is deposited (visceral or subcutaneous). Higher the amount of abdominal fat, the higher is the risk of developing\u00a0Type 2 Diabetes<\/strong>. People who are overall thin, but have high quantities of visceral fat are called\u00a0metabolically unhealthy lean patients<\/strong>. At the same time, people who are obese or have high BMI but little abdominal fat are not at a higher risk of\u00a0T2DM<\/strong>. These set of people are otherwise called\u00a0metabolically healthy obese people.<\/strong><\/p>\r\n\r\n\r\n\r\n

Obesity may not be the one and only cause of diabetes<\/strong><\/p>\r\n\r\n\r\n\r\n

Obesity need not be the only cause of\u00a0T2DM<\/strong>. Other\u00a0causes of diabetes mellitus<\/strong>\u00a0are family history and genetics, sedentary lifestyle, unhealthy eating habits, aging, gestational diabetes, high BP and cholesterol. Let us take up only a few common aspects for discussion now.<\/p>\r\n