Author Archives: prathap
Every year, the World Health Organisation observes April 7th as “World Health Day”, with a focus on a health-related theme of global importance. This year, the theme for World Health Day is “Beat Diabetes’, a slogan which assumes great significance for our centre in its 25th year of service. In consonance with its role as a WHO Collaborating Centre for Noncommunicable Disease, our centre conducted several activities on the occasion of World Health Day. These included quiz programs, healthy recipe demonstrations and diabetes screening camps at several locations including Chennai, Coimbatore, Bhubaneswar and Hyderabad. As a fitting culmination to the day’s activities, we also organized a Panel Discussion entitled “Prevention of Diabetes Needs a Multisectoral Approach” at Chennai.
Doctors are looking into poop samples to check if the bugs in the gut are putting Indians at greater risk for obesity, diabetes and cardiovascular diseases.
Scientists at the Madras Diabetes Research Foundation will sequence the DNA of bacteria in the bowel from the poop that people excreted and see if they have enough of good bacteria or too much of bad bacteria that can trigger metabolic diseases. The research centre has tied up with the University of Copenhagen for the research, which had earlier found strong links between gut bacteria and diabetes. At least 1.5kg of bacteria, living in the human bodies, mostly inside the gut, play an active role beyond digesting food. They are involved in the development and functioning of immune system, neuronal systems and a wide range of metabolic functions, doctors said. On Wednesday, the Danish scientists who spearheaded this research, Dr Oluf B Pedersen, professor of molecular metabolism and metabolic genetics from University of Copenhagen, Denmark, told reporters that the bacterial DNA extracted from stool samples from 292 individuals showed 23% of Danish adults had a 40% reduction in the abundance of bacterial genes.
The DNA sequence of bugs was kind of representation of what is going on in the colon. “We found people with fewer and less diverse bacteria had a higher body fat percentage and elevated blood lipids. This is a significant correlation. We want to know if results are similar in Indians,” said Pedersen. His Indian counterparts have sequenced DNA from bugs of more than 450 stool samples – an equal number of diabetics, pre-diabetes and healthy people. “As of now our hypothesis is that Indians are at greater risk because we have less of the good bacteria that reduce diabetes risk and more of bad bacteria that increases risk,” said diabetologist Dr V Mohan, who heads the research foundation.
There is no adequate evidence to show the link in humans, but stool samples from the lean twin mice given to germ-free mice, make them remain lean and stool from the obese mice and give it to germ-free mice make them obese. “So we can’t rule out that bacteria, in this case, may cause obesity. It may be more than just an innocent bystander,” said Dr Pederson. As of now scientists have no explanation about the exact role of bacteria, but they say evidence show that obese individuals in their colon have a bacterial community that is more efficient at saving energy and so poop out lesser bacteria.
Later during a scientific oration on the bugs in human life, he said looking at the bugs was like moving into a tropical rainforest – there are trillions of them living inside the human body in anaerobic (no oxygen) environment. That means they are difficult to culture in the lab and there can’t be a quick fix solution to refill these bacteria. However, the key to increasing abundance of good bacteria is in the diet.
A study from France showed that when obese people were put on an energy-restricted diet for six weeks, those who were low in bacterial genes, they tended to normalise their abundance of bacterial genes. “That said, I am sure in ten years, we will have enough information to come up with pills packed multi-bacteria from the gut that will prevent or slow down obesity, diabetes and heart diseases,” he said.
The Scientific Committee of Dr. Mohan’s Diabetes Specialties Centre and the Madras Diabetes Research Foundation, Chennai congratulates and salutes, Prof. Oluf Pedersen, Professor of Molecular Metabolism and Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark for his outstanding contributions in the fields of genomics and metagenomics of diabetes and has great pleasure in conferring the ‘25th DMDSC GOLD MEDAL ORATION AWARD’ on him. Dr. S. P. Thyagarajan, Professor of Eminence and Dean-Research, Sri Ramachandra Medical College, Porur, Chennai Presided and Presented the Gold Medal & Certificate to Prof. Oluf Perdersen on Wednesday, 2nd March, 2016.
Dr. Mohan’s Diabetes Specialities Centre, is proud to announce the opening of its 20th branch at Broadway, Chennai on 22th October, 2015.
Inauguration of Dr Rema Mohan High Throughput Sequencing lab at Siruseri today on the 4th anniversary of our beloved Managing Director, late Dr Rema Mohan. This lab is devoted to research on diabetic eye diseases as a tribute to Dr Rema who was a pioneer in the field in India.
Dr. V. Mohan, Chairman, Dr.Mohan’s Diabetes Specialities Centre, delivered his lecture at the “Association of Physicians of India” (API), Dr. Ranjit Unnikrishan, Vice Chairman, Dr. Mohan’s Diabetes Specialities Centre was awarded the Dr. Coelho Memorial Lectureship in Experimental Medicine and Dr.R.M.Anjana, Joint Managing Director, Dr. Mohan’s Diabetes Specialities Centre won the E .Merck Award for the best paper presented at the annual conference of ‘Association of Physicians of India’ (API), conference held in Gurgaon.
Dr. Mohan’s Diabetes Specialities Centre launches Insulin Pump Clinic
Insulin Pump therapy has come as yet another innovation in the field of Diabetes treatments, especially for the patients who are Insulin dependents and who need multiple insulin doses everyday.
Dr. Mohan’s Diabetes Specialities Centre (DMDSC) has today added the ‘Insulin Pump Clinic’ facility in it’s Gopalapuram Centre in Chennai.
Dedicating the facility, Dr. V. Mohan, Chairman, DMDSC said, “an insulin pump is a small device about the size of a small cell phone that is worn externally and can be discreetly clipped to your belt, slipped into a pocket, or hidden under your clothes. It delivers precise doses of rapid-acting insulin to closely match your body’s needs”.
“Small amounts of insulin delivered continuously (24/7) for normal functions of the body (not including food). The programmed rate is determined by our specialists based on the patient’s Diabetes condition. Insulin pumps have bolus calculators that help patients to calculate their bolus amount based on settings that are fixed by our specialists”, he added.
During a live interaction with patients on the occasion, Dr. V. Mohan further explained, “since the insulin pump uses only more predictable rapid-acting insulin, patients need not follow a strict schedule for eating, activity, and insulin injections. They have the freedom of eating only when hungry, delaying a meal if required or even broadening the food choices”.
“With insulin pump therapy, patients will have to change their infusion set only a few times per month unlike conventional multiple daily injections”, he added.
Dr. R. M. Anjana, Joint Managing Director further explained “we have introduced ‘Try Before You Buy’ (TBYB) scheme for the patients who want to try the pump and get used to it before actually buying one. The insulin pumps are available for a minimum monthly rent under this scheme, without any caution deposit, which we introduce in the interest of the patients. Patients can decide after a month or two of trial use, whether they want to buy the pump or not.”
With proper insulin pump use, patients can be four times more likely to achieve their target A1C and potentially reduce their low blood sugar reactions by 84%. Since insulin pump therapy can help achieve better control, it can reduce long-term complications of diabetes such as eye, heart, kidney, and nerve damage.
Inauguration of the department of Physical Activity Research at MDRF on 25th September, 2014 by Dr. V. Mohan, Chairman, DMDSC
Obesity Reduction and Awareness of Non-communicable diseases through Group Education (ORANGE) Phase II
A training program as part of Obesity Reduction and Awareness of Non-communicable diseases through Group Education (ORANGE) Phase II was organized by the Department of Translational Research and led by Dr. Ranjani Harish, Sr. Scientist and Head of the department. The training program on combating obesity and diabetes in children and adolescents through a school based co-curriculum intervention was held on 22nd of August 2014 at the Madras Diabetes Research Foundation (MDRF) Auditorium, Gopalapuram, Chennai. The students of classes VI and VII and the teachers were sensitized about diabetes, obesity and its prevention. In addition, Dr. V. Mohan, Chairman, Dr.Mohan’s Diabetes Specialities Centre (DMDSC) and President (MDRF) and Dr. R.M. Anjana, Joint Managing Director (DMDSC) felicitated the gathering by motivating them on the importance of healthy eating habits and physical activity. Teachers, physical trainers and peer leaders from eight different schools benefited from this program. The program was concluded with distribution of certificates and some physical exercises.
We thank the schools – Chinmaya Vidyalaya, Virugambakkam; Sri Sathya Sai, Thiruvottiyur; Sri Sathya Sai, Chrompet; Sri Sankara, Adyar; Sri Vishwa Vidyalaya, Otteri; Bhaktavatsalam, Korattur; Besant Theosophical, Besant Nagar; Dhanakotti, Chintadripet; for their enthusiastic participation.